7/5/2023 0 Comments Caffeine half life![]() ![]() This study from the American Journal of Clinical Nutrition represents a departure from some others which found that high caffeine consumption and CYP1A2 do not mix. Other symptoms included tachycardia and increased respiration. To quote this old paper published by the military:Įxtreme side effects were observed in humans at caffeine intakes of 1 g (15 mg/kg) (Gilman et al., 1990), including restlessness, nervousness, and irritability, and progressing to delirium, emesis, neuromuscular tremors, and convulsions. One thing I find funny about the study is setting the upper limit of 5-6 cups as “healthy.” That’s a ton of caffeine! Depending on strength of the coffee, 5 cups in a day is close to, or above, 1 gram of caffeine, which has been described in the medical literature as the threshold when very severe side effects can develop. But be warned, they do say that drinking more than 5-6 cups of coffee per day is probably a bad idea and might play a role in increasing your risk for heart disease by as much as 22 percent. In fact, the authors found that drinking moderate amounts of coffee was probably good for your heart. One of the latest studies to look at the issue of caffeine consumption and genetics, which was published in the American Journal of Clinical Nutrition, found no increased risk for CYP1A2 genotypes when consuming moderate amounts of coffee. Genetic studies looking at how caffeine consumption can impact heart health are mixed, with some showing no increased risk for slow caffeine metabolizers, and others flashing warning signs. And drinking coffee in moderation can be very healthy if you have the right genes. In the standard western diet, coffee, which is chock full of polyphenols, is actually one of the primary sources of antioxidants for many Americans. For those who carry the CYP1A2 gene associated with slower caffeine clearance, caffeine has a much bigger impact than it might on someone who carries a different variant of the gene. The half life of a drug like caffeine is the amount of time the drug is active before it is fully metabolized by the body. The speed with which we break down caffeine determines the half life of the drug in our system. Where do you fit?īy contrast, some of us are fast metabolizers of caffeine. ![]() We score for fat metabolism, histamine clearance, carbohydrate tolerance, and more. Gene Food uses a proprietary algorithm to divide people into one of twenty diet types based on genetics. ![]() Slow metabolizers are more likely to have caffeine induced anxiety, sleep problems, and even high blood pressure as a result of having that morning cup of coffee. ![]() 1 Your CYP1A2 status determines how fast your body will clear the caffeine you drink. Variants in a gene called CYP1A2 determine how fast your liver metabolizes caffeine. Some of us get rid of it fast, others, who have less enzyme activity, much slower. But here’s the deal: not everyone is born with the same enzyme activity for metabolizing caffeine. When we drink caffeine, enzymes in the body break the drug down and get it out of our system. Ninety percent of Americans drink some form of caffeinated beverage every morning.Īnd while, the coffee culture in the United States is ubiquitous no matter what hamlet you call home, people respond differently to caffeine based in part on genetics. To say coffee is popular is quite the understatement. Let’s have a look at the genes that drive differences in caffeine metabolism. Ever wonder why some of us can drink an espresso right before bed and still get our 8 hours, while others will be staring at the ceiling all night? The answer lies in our genetics. ![]()
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